I use a capo on the keyboard. Sounds funny, but that's basically what the transpose function is.

When sequencing and recording, I really suck as a keyboardist, and I can only play "sort of well" in a few keys. So I play in those keys and transpose. It's no different than using a capo on a guitar.

Vocally, I sing best in the keys of F and Eb. So I play the songs in C or G, and let the tools do the hard work.

In the long run, it's the final song that counts, not the tools you used to create it, so nothing else should matter.