HA! Looks like my (meant-to-be-humourous) comments about "right-handers playing wrong" stirred up some controversy.

In reality, I play the way I do simply because right handed instruments are much easier to find. It wasn't because one way was easier or more comfortable than the other. To me it was simply a matter of availability.
The interesting thing I've found over the years is that the mandolin and greek bouzouki are tuned like the bottom 4 strings of the guitar but in reverse - low to high GDAE. So the quickest way to play chords is to think mirror image of guitar chords. You gotta be in your right-mind to play like that on the fly.

The only instrument I play reversed is the Chinese Guzcheng.The string farthest away is highest pitch, versus the traditional setup. I did it this way simply because that's how Andreas Vollenweider has his set up. Try to find some lessons on the Guzcheng anyway - I don't think anyone notices the backwards setup.